Endocrine Abstracts

The hypothalamo-pituitary–thyroid (HPT) axis serves to maintain appropriate systemic levels of thyroid hormone (TH) through a negative feedback pathway via the hypothalamic arcuate and paraventricular nuclei. However, the effects of TH in other hypothalamic regions are poorly understood. Triiodothyronine (T3) administration to the hypothalamic ventromedial nucleus (VMN) induces a potent hyperphagic response, although it is unclear whether this is part of a nove...

Hypoglycaemia and hypoglycaemia unawareness severely limit the optimal management of diabetes mellitus and cause recurrent morbidity and even mortality in intensively controlled patients. Altered hypothalamic glucose sensing has been implicated in the development of defective counter regulatory responses to insulin induced hypoglycaemia and hypoglycaemic unawareness. This change in hypothalamic glucose sensing has been attributed, at least in part, to an increase in glucokinas...

The hypothalamo-pituitary–thyroid (HPT) axis maintains controlled systemic levels of thyroid hormone (TH). This is achieved through negative feedback via the hypothalamic arcuate and paraventricular nuclei. The effects of thyroid hormone in other hypothalamic nuclei are yet to be elucidated. Administration of triiodothyronine (T3, thyroid hormone) into the hypothalamic ventromedial nucleus (VMN) increases food intake in rats. Thyroid hormone activation and inac...